Pii: 0090-6980(83)90152-1
نویسندگان
چکیده
Mononuclear phagocytes are undoubtedly the sine qua non of chronic inflammatory reactions. This is demonstrated by their unique ability to function as phagocytic, secretory, or effector cells during the course of an immune event. Although macrophages can perform a variety of immune tasks, their ability to function appropriately is dependent upon the mode of elicitation, the stimulus under investigation, the source of the macrophages (peritoneal, alveolar, etc.), and whether the macrophages are monolayers or in suspension. We have examined the relationship between adherent and non-adherent elicited peritoneal macrophages in terms of prostaglandin E (PGE ) and superoxide anion (0 ) production; in addition, su pension P we have studied t ese e lcited macrophages in h? z. for their ability to undergo transmembrane potential changes in response to several stimuli. Non-adherent, elicited peritoneal macrophages demonstrated an increase in basal PGE production, and were refractory to particulate stimulus. After monolayer fgrmation basal PGE levels dropped and the cells could respond to both soluble and part;culate stl .& uli. On_ly adherent macrophages could respond to a specific challenge and synthesize 0 . Both 0 oroduction and deoolarization of the transmembrane potential were ?i I cells in suspens'ion. both exogenous PGE su pressed ?I Furthermore, and super-n&ant from macrophaaes in suspension could modulate 0, product on ? macrophages monolayer-s. These studies indicate that PGE by PMA challenged phage function and dictate activity as macrophages go fr c&l may modulate macrothe non-adherent to
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Pii: 0014-4886(76)90152-7
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